It is used in aesthetic medicine for the correction of skin defects, natural rejuvenation and restoration of lost subcutaneous integuments. Stimulates the production of collagen, supports the physical activity of the skin and replenishes volumes. The hybrid action of EtreBelle fillers is based on a combination of polylactic acid and sodium hyaluronate. Getting under the skin, hyaluron fills wrinkles and defects, providing an instant aesthetic effect. PLA "cements" the hyaluron, preventing it from migrating from the injection site and ensuring the integrity of the hydrogel. After 1 month, hyaluron begins to hydrolyze, and PLA microparticles contribute to the production of collagen and lead to an even more elastic state of the skin. After 6 months, the biodegradation of hyaluron begins, which is gradually replaced by collagen fibers synthesized by PLA. As a result, physical support restores the volume of the skin and maintains a natural result for up to 2 years. Indications: perioral wrinkles, nasolabial wrinkles, marionette wrinkles, asymmetry of parts of the face, correction of contours and increase in volume, age-related skin changes. Side effects: short-term redness, itching, swelling at the injection sites. A course of restorative massage of the injection zone is recommended within 3 days after the procedure. Contraindications for use: allergy to the components of the drug; skin infections in the injection area; pregnancy and lactation; autoimmune disorders; possibility of keloid formation. Clinical result: smoothing wrinkles, scars, folds and furrows; deep skin hydration; restoration of natural volumes; correction of aesthetic defects;