< p>FEATURES AND BENEFITS: The combination of the active components-enrofloxacin and colistin sulfate-having a synergistic effect, provides a wide range of antibacterial and mycoplasma effects.The combination of enrofloxacin and colistin sulfate prevents the rapid development of resistance of microorganisms to fluoroquinolones.Ease of dosage and application.Short course of treatment — 5 days!Description: Arrestin — a broad-spectrum drug for the treatment of diseases of antibacterial and mycoplasma etiology.Enrostin is prescribed for therapeutic purposes to young cattle and small cattle, pigs and poultry for respiratory and gastrointestinal diseases, colibacteriosis, salmonellosis, streptococcosis, necrotic enteritis, hemophilosis, mycoplasmosis, mixed and secondary infections in viral diseases and other diseases whose pathogens are sensitive to enrofloxacin and colistin.Description: Arrestin — a broad-spectrum drug for the treatment of diseases of antibacterial and mycoplasma etiology.Enrostin is prescribed for therapeutic purposes to young cattle and small cattle, pigs and poultry for respiratory and gastrointestinal diseases, colibacteriosis, salmonellosis, streptococcosis, necrotic enteritis, hemophilosis, mycoplasmosis, mixed and secondary infections in viral diseases and other diseases whose pathogens are sensitive to enrofloxacin and colistin.General information: 1.Trade name of the medicinal product: Arrestin (Enrostin).International nonproprietary name: enrofloxacin, colistin. 2. Dosage form: solution for oral administration.Enrostin as active ingredients in 1 ml contains: enrofloxacin-100 mg and colistin sulfate-106 IU, as well as auxiliary substances: benzyl alcohol, sodium metabisulfite, lactic acid, synthanol and purified water.3. In appearance, the drug is a liquid from light yellow to yellow in color; during storage, a slight turbidity is allowed, which disappears after shaking.The shelf life of Enrostine under the conditions of storage in the closed packaging of the manufacturer is 2 years from the date of production, after opening the bottle-no more than 28 days. < p>The use of Enrostine after the expiration date is prohibited.4. Enrostin is produced packaged in 5 and 10 ml glass and polymer dropper bottles, complete with screw-on lids and dropper stoppers, and 100 ml in polymer bottles, complete with screw-on lids. Vials of 5, 10 and 100 ml are packed individually, vials of 5 and 10 ml are also packed in 10 vials in packs of cardboard, complete with instructions for use. Bottles of 1 liter of polymer materials are sealed with lids and provided with instructions for use. 5. Store the drug in the closed packaging of the manufacturer, in a place protected from direct sunlight, separate from food and feed, at a temperature of 5 °C to 25 °C.6. Arrestin should be stored in places inaccessible to children.7. Unused medicinal product is disposed of in accordance with the requirements of the legislation.8. Conditions of release: without a prescription from a veterinarian. < p>Pharm. Sv-va: 9. Arrestin refers to a combination of antibacterial drugs. 10. The combination of enrofloxacin and colistin sulfate, which are part of the drug, provides a wide range of its antimicrobial activity. Enrofloxacin belongs to the fluoroquinolone group of compounds, the mechanism of action of which is based on inhibition of the activity of the gyrase enzyme affecting replication of DNA spiral in nucleus of bacterial cells, leading to suppression of growth and development of gram-positive and gram-negative bacteria, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Bordetella spp., Campylobacter spp. Corynebacterium pyogenes, Pseudomonas aeruginosa and Mycoplasma spp.Colistin Sulfate – the compound of a group of polypeptide antibiotics, disrupting the permeability of the bacterial cell wall by combining with lipoproteins, causes changes in intracellular metabolism and the death of Gram-negative bacteria, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp., Salmonella spp., Proteus spp.After oral administration of the drug, enrofloxacin is well and quickly absorbed in the gastrointestinal tract and penetrates into most organs and tissues; excreted unchanged and partially as metabolites, mainly with urine and in small amounts in feces; colistin sulfate is practically not absorbed in the gastrointestinal tract, does not accumulate in the organs and tissues of the body are excreted mainly unchanged in the faeces. According to the degree of exposure to the body, Enrostine belongs to moderately dangerous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses it is well tolerated by animals, does not have embryotoxic and teratogenic properties.Application procedure: 12. Contraindication to use is the hypersensitivity of the animal to the components of the drug. It is forbidden to use Enrostin to laying hens and repair young animals less than 2 weeks before the start of egg laying, due to the accumulation of enrofloxacin in the eggs. It is not allowed to use Enrostin in adult ruminants with developed cicatricial digestion, piglets weighing less than < p>20 kg, animals with severe disorders of the development of cartilage tissue, severe kidney and/or liver diseases, with lesions of the nervous system accompanied by convulsions, pregnant and lactating sows.13. Enrostin is administered to animals orally once a day for 3 to 5 days, in the following doses: - calves, lambs, pigs-0.3 ml/kg of animal weight, drinking with water for drinking in a 1:1 dilution; in the severe form of the disease, the daily dose of the drug is increased to 0.5 ml/kg of animal weight; < p>- broilers, breeding poultry, repair young chickens, parent broiler herd and meat turkeys – 0.5 ml/l of water for drinking.In salmonellosis, mixed infections, as well as in chronic forms of avian diseases, the course of treatment is extended to 7 days.During the treatment period, the bird should only receive water containing the drug. The therapeutic solution is prepared daily in a volume calculated for the consumption of poultry during the day.14. With an overdose of the drug, the animal may experience a decrease in appetite, depression, vomiting, diarrhea. 15. Features of the action at the first use of the drug and at its cancellation were not revealed. 16. It is not allowed to use Enrostin to pregnant and lactating sows, as well as laying hens and repair young animals less than 2 weeks before the start of egg laying.17. You should avoid skipping the next dose of the drug, as this can lead to a decrease in effectiveness. In case of missing one dose, the use of the drug is resumed at the same dose according to the same scheme.18. When applying Annastina in accordance with this instruction side effects and complications are usually not observed. With increased individual sensitivity to the components of the drug and the development of allergic reactions, the use of Enrostine is discontinued and desensitizing therapy is performed.19. Enrostin should not be used simultaneously with levomycetin, macrolides, tetracyclines, theophylline, polyester ionophores, nonsteroidal anti-inflammatory drugs, drugs containing magnesium, aluminum and calcium cations, which, binding to enrofloxacin, prevent its adsorption.20. Slaughter of birds for meat is allowed no earlier than 11 days; calves, lambs and pigs-no earlier than 14 days after the last use of the drug. The meat of animals that were forcibly killed before the expiration of these terms can be used as food for fur-bearing animals.Preventive measures: 21. When working with Enrostine, you should follow the general rules of personal hygiene and safety, provided for when working with medicines. 22. It is forbidden to smoke, drink or eat while working. At the end of working with the drug, you should thoroughly wash your face and hands with soap. Empty packaging from under the drug is forbidden to use for household purposes, it is subject to disposal with household waste. People with hypersensitivity to the components of the drug should avoid direct contact with the drug Enrostin.23. If the drug gets on the skin or mucous membranes, it is necessary to immediately wash them with plenty of water. In case of allergic reactions or accidental ingestion of the drug in the human body, you should immediately contact a medical institution (you should have the instructions for use or the label). Name and address of the production site of the manufacturer of the medicinal product for veterinary use: LLC NPO Api-San, Moscow region, Balashikha district, Poltevskoe highway, possession 4.Name, address of the organization authorized by the holder or owner of the registration certificate of the medicinal product to accept claims from the consumer: LLC NPO Api-San, Moscow region, Balashikha district, Poltevskoe highway, possession 4.